London: A comprehensive study led by the University of Exeter has uncovered 15 lifestyle and health factors associated with the risk of young-onset dementia (YOD), affecting individuals under 65. Analyzing data from 356,052 participants in the UK, the research identifies factors such as low socioeconomic status, social isolation, hearing impairment, stroke, diabetes, heart disease, and depression as contributors to YOD risk.
The study, described as the largest of its kind, also highlights vitamin D deficiency, elevated C-reactive protein levels (indicative of inflammation), and possession of two ApoE4 ε4 gene variants as risk factors.
The relationship between alcohol and YOD is termed “complex,” with alcohol abuse increasing risk, while moderate to heavy drinking correlates with a reduced risk, potentially due to overall better health in this group. On the positive side, higher levels of formal education and lower physical frailty, measured through handgrip strength, were associated with a lower YOD risk.
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